APO-go® (apomorphine) is a dopamine receptor agonist (DA). Dopamine receptor agonists are drugs which have structures that are very similar to dopamine itself. They imitate the action of dopamine rather than replace it in the way levodopa does.
Dopamine is a neurotransmitter (chemical messenger). It enables the brain to transmit signals from one area to another, which allow the brain to control and co-ordinate body movements.
Parkinson’s disease (Pd) is caused by a loss of dopamine-producing cells in specific areas of the brain including those that control movement. These cells continue to be lost as the disease progresses and as a result the brain loses its ability to produce dopamine.
Apomorphine is known as a D1/D2 receptor agonist, since it stimulates the D1 and D2 dopamine receptors. Some dopamine agonists stimulate a single set of dopamine receptors and others stimulate a number of these groups of receptors. D1 and D2 receptors are important in producing smooth voluntary movement.
Apomorphine – is that Morphine?
Apomorphine is a different drug to morphine and it is not a narcotic.
Apomorphine is specifically used to treat Parkinson’s disease